| The Ironclad | Exhaust / Infinite | S | | THE dominant Ironclad strategy. Force infinite via Exhaust loops. Bloodletting at Common makes it accessible. |
| The Silent | Sly/Discard | S | | Most powerful archetype in STS2 per top player analysis. Sly mechanic is considered overtuned — cards play free when discarded. |
| The Necrobinder | Doom Stacking | S | | Highest damage ceiling. Doom threshold instant-kills. |
| The Necrobinder | Osty Tank | S | | Osty absorbs all damage. Very safe when managed correctly. |
| The Defect | Orb/Focus | S | | Focus scaling amplifies all Orbs. Frost for defense, Lightning/Dark for offense. |
| The Silent | Poison | S | | Reliable but overshadowed by Sly. Still strong for A10. |
| The Regent | Stars Build | S | | Uncapped Stars scaling. High ceiling but requires patience. |
| The Ironclad | Block/Body Slam | A | | Very defensive. Body Slam converts Block to damage. |
| The Ironclad | Vulnerable | A | | New STS2 archetype replacing Strength builds. Apply Vulnerable, capitalize with damage. |
| The Defect | Claw/Zero-Cost | A | | Claw grows permanently. All for One recalls 0-cost cards. |
| The Regent | Forge Build | A | | Sovereign Blade gains permanent damage. Scales infinitely. |
| The Necrobinder | Soul Cycle | A | | Draw engine via Soul cycling. Near-infinite when assembled. |
| The Regent | Stars+Forge Hybrid | A | | Flexible approach. Take what the run offers. |
| The Silent | Shiv | B | | Needs Accuracy to work. Fun but less consistent. |
| The Defect | Creative AI | B | | Niche. Only works if Creative AI appears early. |