STS2 Builds

Community-sourced build guides for Slay the Spire 2 (A10+). Card tier lists, synergy maps, and act-by-act walkthroughs compiled from the best runners in the community.

Choose a Character

The Ironclad

S

The last soldier of the Ironclads. In STS2, the dominant strategy is Exhaust/Infinite — assembling Corruption + Dark Embrace + Bloodletting to go infinite. Vulnerable is the new damage-scaling archetype replacing the old Strength builds.

3 builds

Aggressive warrior with self-healing

The Necrobinder

S

A Spireborn Lich who commands Osty, a skeletal companion that absorbs all incoming damage. At 66 HP the most fragile character in the game, but compensates with Doom stacking (instant-kill threshold), Soul cycling draw engines, and the strongest overall damage ceiling in STS2.

3 builds

Lich with skeletal companion, Doom thresholds, and Soul cycling

The Regent

S

The cosmic prince and one of the strongest characters in STS2. Stars persist between turns with no cap, enabling massive scaling. Sovereign Blade gains permanent damage through Forging. Hardest character to pilot but has the highest ceiling in the game.

3 builds

Cosmic scaling with Stars resource and Forge weapon upgrades

The Silent

S

An assassin from the Foglands. The Sly discard mechanic makes Silent arguably the strongest character in STS2 — cards play for free when discarded, enabling explosive combo turns. Also supports Poison and Shiv builds, though Sly outperforms both.

3 builds

Assassin with poison and discard synergies

The Defect

A

An awakened automaton of unknown origin. Channels Orbs — Lightning, Frost, Dark, and Plasma — amplified by Focus scaling. The least changed character from the original game, offering reliable mechanical depth through Orb management and zero-cost card spam. JapaneseExport notes Defect's orb system excels in fights that allow setup time, and the current game doesn't punish slow setup enough — making Defect feel slightly too strong.

3 builds

Orb-channeling automaton with Focus scaling

What Makes This Different

  • Sourced from top players

    Every card rating and strategy is backed by evidence from high-Ascension runners — no assumed tier lists.

  • Act-by-act walkthroughs

    Each build guide walks through priorities, card picks, removals, and key decisions for every act.

  • Infinite strategies

    Detailed setup and execution steps for every viable infinite, including online signals and counterplay warnings.

  • Multiplayer tips

    Dedicated sections covering how each build adapts to co-op — which cards gain value, which lose it, and how to coordinate.